Responsible for the influence of those who are going to see that design.
The idea of being responsible for a creation reminds me to the book of Frankenstein writen by Mary Shelley. The book describes the obsession of a creator (life designer in this case) ignoring all the moral principles and trying to be god, and how his creation destroys him and all the beauty in his life. His irresponsibility gives the world the most horrific creature. In this way, the book shows a symbolic representation of the consecuences of the irresponsibility.
I started the post with this reference because I don´t think that all the designers are responsible for their work, but ideally a designer should be responsible. Otherwise, the creations will be monster to the culture.